Early life, life course and gender influences on levels of C-reactive protein among migrant Bangladeshis in the UK.

ABSTRACT:

Background and objectives

Humans co-evolved with pathogens, especially helminths, that educate the immune system during development and lower inflammatory responses. The absence of such stimuli in industrialized countries is associated with higher baseline levels of C-reactive protein (CRP) among adults who appear at greater risk for inflammatory disorders. This cross-sectional study examined effects of early life development on salivary CRP levels in 452 British-Bangladeshis who spent varying periods growing up in Bangladesh or UK. We also analyzed how gender and central obesity modulate effects on CRP. We hypothesized that: (i) first-generation Bangladeshis with higher childhood exposure to pathogens would have chronically lower CRP levels than second-generation British-Banglades

SUBMITTER: Begum K 

PROVIDER: S-EPMC8754477 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature