Altered cerebrocerebellar functional connectivity in patients with obstructive sleep apnea and its association with cognitive function.

ABSTRACT:

Study objectives

Previous functional MRI studies have reported altered brain networks in patients with obstructive sleep apnea (OSA). However, the extent and pattern of abnormal connectivity were inconsistent across studies, and cerebrocerebellar connections have been rarely assessed. We investigated functional network changes in cerebral and cerebellar cortices of OSA patients.

Methods

Resting-state functional MRI, polysomnography, and neuropsychological (NP) test data were acquired from 74 OSA patients (age: 45.8 ± 10.7 years) and 33 healthy subjects (39.6 ± 9.3 years). Connectivity matrices were extracted by computing correlation coefficients from various regions of interest, and Fisher r-to-z transformations. In the functional connections that showed significant group di

SUBMITTER: Park HR 

PROVIDER: S-EPMC8754484 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature