Cortical thinning and sleep slow wave activity reductions mediate age-related improvements in cognition during mid-late adolescence.

ABSTRACT: Gains in cognitive test performance that occur during adolescence are associated with brain maturation. Cortical thinning and reduced sleep slow wave activity (SWA) are markers of such developmental changes. Here we investigate whether they mediate age-related improvements in cognition. 109 adolescents aged 15-19 years (49 males) underwent magnetic resonance imaging, polysomnography (PSG), and a battery of cognitive tasks within a 2-month time window. Cognitive tasks assessed nonverbal intelligence, sustained attention, speed of processing and working memory and executive function. To minimize the effect of sleep history on SWA and cognitive performance, PSG and test batteries were administered only after at least 8 nights of 9-h time-in-bed (TIB) sleep opportunity. Age-related improvement

SUBMITTER: Ong JL 

PROVIDER: S-EPMC8754498 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature