Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function.

ABSTRACT:

Purpose

Critically ill patients with preserved or increased renal function have been shown to be at risk of underexposure to meropenem. Although many meropenem population pharmacokinetic (PK) models have been published, there is no large prospective population PK study with rich sampling focusing on patients most at risk of suboptimal pharmacokinetic/pharmacodynamic (PK/PD) target attainment. Therefore, the aim of the present study was to evaluate PK/PD target attainment and to perform a thorough covariate screening using population PK modelling of meropenem in septic patients with preserved or increased renal function.

Patients and methods

A single-centre prospective observational PK study was performed in the intensive care unit (ICU) of the University Hospitals Leuven. Pa

SUBMITTER: Gijsen M 

PROVIDER: S-EPMC8754504 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature