Dietary Mediators of the Genetic Susceptibility to Obesity-Results from the Quebec Family Study.

ABSTRACT:

Background

Recent studies showed that eating behaviors such as disinhibition, emotional and external eating, and snacking mediate genetic susceptibility to obesity. It remains unknown if diet quality and intake of specific food groups also mediate the genetic susceptibility to obesity.

Objective

This study aimed to assess if diet quality and intakes of specific food groups mediate the association between a polygenic risk score (PRS) for BMI and BMI and waist circumference (WC). We hypothesized that poor diet quality, high intakes of energy-dense food groups, and low intakes of nutrient-dense food groups mediate the genetic susceptibility to obesity.

Methods

This cross-sectional study included 750 participants (56.3% women, aged 41.5 ± 14.9 y, BMI 27.8 ± 7.5 kg/m2) fro

SUBMITTER: Jacob R 

PROVIDER: S-EPMC8754573 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature