The Plasma Proteome Fingerprint Associated with Circulating Carotenoids and Retinol in Older Adults.

ABSTRACT:

Background

Although diets rich in carotenoids are associated with reduced risks of cardiovascular disease, age-related macular degeneration, disability, and other adverse aging outcomes, the underlying biological mechanisms are not fully elucidated.

Objectives

To characterize the plasma proteome fingerprint associated with circulating carotenoid and retinol concentrations in older adults.

Methods

In 728 adults ≥65 y participating in the Invecchiare in Chianti (InCHIANTI) Study, plasma α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin, and lycopene were measured using HPLC. The SOMAscan assay was used to measure 1301 plasma proteins. Multivariable linear regression models were used to examine the relationship of individual carotenoids and retinol with plasma

SUBMITTER: Yamaguchi Y 

PROVIDER: S-EPMC8754576 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature