Higher diet quality relates to decelerated epigenetic aging.

ABSTRACT:

Background

DNA methylation-based epigenetic age measures have been used as biological aging markers and are associated with a healthy lifespan. Few population-based studies have examined the relation between diet and epigenetic age acceleration.

Objectives

We aimed to investigate the relation between diet quality and epigenetic age acceleration.

Methods

We analyzed data from 1995 participants (mean age, 67 years; 55% women) of the Framingham Heart Study Offspring Cohort. Cross-sectional associations between the Dietary Approaches to Stop Hypertension (DASH) score and 3 whole-blood DNA methylation-derived epigenetic age acceleration measures-Dunedin Pace of Aging Methylation (DunedinPoAm), GrimAge acceleration (GrimAA), and PhenoAge acceleration (PhenoAA)-were examined

SUBMITTER: Kim Y 

PROVIDER: S-EPMC8755029 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature