Dataset Information

Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers.

ABSTRACT:

Background

The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19).

Methods

A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination.

Results

The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found.

Conclusions

The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.

SUBMITTER: Kristensen JH

PROVIDER: S-EPMC8755365 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers.

Kristensen Jonas Henrik JH Bo Hasselbalch Rasmus R Pries-Heje Mia M Nielsen Pernille Brok PB Nielsen Pernille Brok PB Dehlbæk Knudsen Andreas A Fogh Kamille K Boesgaard Norsk Jakob J Eiken Aleksander A Andersen Ove O Fischer Thea Kølsen TK Juul Jensen Claus Antonio CA Torp-Pedersen Christian C Rungby Jørgen J Ditlev Sisse Bolm SB Hageman Ida I Møgelvang Rasmus R Gybel-Brask Mikkel M Dessau Ram Benny RB Sørensen Erik E Harritshøj Lene L Folke Fredrik F Engel Møller Maria Elizabeth ME Benfield Thomas T Ullum Henrik H Sværke Jørgensen Charlotte C Rye Ostrowski Sisse S Dam Nielsen Susanne S Bundgaard Henning H Iversen Kasper K

The Journal of infectious diseases 20220801 1

<h4>Background</h4>The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19).<h4>Methods</h4>A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination.<h4>Results</h4>The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with u ...[more]

PMID: 34989811

Similar Datasets

Project description:BackgroundA variety of circumstances can influence how widely vaccination during pregnancy is accepted. Healthcare workers (HCWs) are often seen as the main resource for recommending vaccination. The purpose of the current study was to determine whether Italian HCWs advise and recommend pregnant people to receive the influenza vaccinations, as well as what knowledge and attitudes affect their practices. A secondary aim of the study was to evaluate HCWs' knowledge and attitudes towards COVID-19 vaccination.MethodsThis cross-sectional study, took place between August 2021 and June 2022 in a randomly selected sample of HCWs in three Italian regions. The target population comprised obstetricians-gynecologists, midwives and primary care physicians, who provide medical care to pregnant people. The questionnaire consisted of 19 items divided into 5 parts gathered information about the participants' sociodemographic and professional characteristics, general knowledge about vaccinations during pregnancy, and vaccine-preventable diseases (VPDs), attitudes and practices towards immunization, and strategies to potentially increase vaccination uptake during pregnancy.ResultsAmong the participants, 78.3% knew that pregnant people are at increased risk of severe complications from influenza, 57.8% that the influenza vaccine is not provided only in the 2nd/3rd trimester of pregnancy and 60% that pregnancy is a risk factor for severe COVID-19 infection. Of the enrolled HCWs, 10.8% believed that the potential risks of vaccines administered during pregnancy are greater than the benefits. An even higher proportion of the participants was unsure (24.3%) or did not deem (15.9%) that vaccinating against influenza during pregnancy reduces the risk of preterm birth and abortion. Moreover, 11.8% of the sample did not believe or was uncertain that COVID-19 vaccine must be offered to all pregnant people. Among HCWs, 71.8% advised women about influenza vaccination during pregnancy, and 68.8% recommended getting vaccinated against influenza during pregnancy. Results showed that good knowledge and positive attitudes were the strongest factors positively associated with advising women about influenza vaccination during pregnancy.ConclusionThe gathered data showed that a sizable portion of the HCWs lacks up-to-date knowledge, underestimates the risks of contracting a VPD, and overestimates the risks of vaccine side effects during pregnancy. The findings shed light on such attributes useful to promote adherence to evidence-based recommendations among HCWs.

Dataset Information

Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers.

Background

Methods

Results

Conclusions

Publications

Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers.

Similar Datasets

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