Modelling upper respiratory viral load dynamics of SARS-CoV-2.

ABSTRACT: Relationships between viral load, severity of illness, and transmissibility of virus are fundamental to understanding pathogenesis and devising better therapeutic and prevention strategies for COVID-19. Here we present within-host modelling of viral load dynamics observed in the upper respiratory tract (URT), drawing upon 2172 serial measurements from 605 subjects, collected from 17 different studies. We developed a mechanistic model to describe viral load dynamics and host response and contrast this with simpler mixed-effects regression analysis of peak viral load and its subsequent decline. We observed wide variation in URT viral load between individuals, over 5 orders of magnitude, at any given point in time since symptom onset. This variation was not explained by age, sex, or severity

SUBMITTER: Challenger JD 

PROVIDER: S-EPMC8755404 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature