Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections.

ABSTRACT: MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. However, its mechanism of action remains poorly understood. Here, we find that intranasal prophylaxis with MV130 modulates the lung immune landscape and provides long-term heterologous protection against viral respiratory infections in mice. Intranasal administration of MV130 provides protection against systemic candidiasis in wild-type and Rag1-deficient mice lacking functional lymphocytes, indicative of innate immune-mediated protection. Moreover, pharmacological inhibition of trained immunity with metformin abrogates the protection conferred by MV130 against influenza A virus respiratory infection. MV130 induces reprogramm

SUBMITTER: Brandi P 

PROVIDER: S-EPMC8755442 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature