U-shaped relationship between urea level and hepatic decompensation in chronic liver diseases.

ABSTRACT:

Background/aims

We aimed to determine the association between blood urea level and incident cirrhosis, hepatic decompensation, and hepatocellular carcinoma in chronic liver disease (CLD) patients.

Methods

The association between blood urea level and liver fibrosis/liver-related events were evaluated on continuous scale with restricted cubic spline curves based on generalized additive model or Cox proportional hazards models. Then, the above associations were evaluated by urea level within intervals.

Results

Among 4,282 patients who had undergone liver stiffness measurement (LSM) by transient elastography, baseline urea level had a U-shaped association with LSM and hepatic decompensation development after a median follow-up of 5.5 years. Compared to patients with urea

SUBMITTER: Lin H 

PROVIDER: S-EPMC8755470 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature