Cancer risk across mammals.

ABSTRACT: Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations^1,2. While elevated cancer risk with larger body size and/or longevity has been documented within species^3-5, Peto's paradox indicates the apparent lack of such an association among taxa⁶. Yet, unequivocal empirical evidence for Peto's paradox is lacking, stemming from the difficulty of estimating cancer risk in non-model species. Here we build and analyse a database on cancer-related mortality using data on adult zoo mammals (110,148 individuals, 191 species) and map age-controlled cancer mortality to the mammalian tree of life. We demonstrate the

SUBMITTER: Vincze O 

PROVIDER: S-EPMC8755536 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature