Insect protease inhibitors; promising inhibitory compounds against SARS-CoV-2 main protease.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has adversely affected global health since its emergence in 2019. The lack of effective treatments prompted worldwide efforts to immediately develop therapeutic strategies against COVID-19. The main protease (M^pro) of SARS-CoV-2 plays a crucial role in viral replication, and therefore it serves as an attractive target for COVID-19-specific drug development. Due to the richness and diversity of insect protease inhibitors, we docked SARS-CoV-2 M^pro onto 25 publicly accessible insect-derived protease inhibitors using the ClusPro server, and the regions with high inhibitory potentials against M^pro were used to design peptides. Interactions o

SUBMITTER: Hemmati SA 

PROVIDER: S-EPMC8755557 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature