Oral Cyanobacteria and Hepatocellular Carcinoma.

ABSTRACT:

Background

Gut microbial alterations have been linked to chronic liver disease and hepatocellular carcinoma (HCC). The role of the oral microbiome in liver cancer development has not been widely investigated.

Methods

Bacterial 16S rRNA sequences were evaluated in oral samples from 90 HCC cases and 90 controls who were a part of a larger U.S. case-control study of HCC among patients diagnosed from 2011 to 2016.

Results

The oral microbiome of HCC cases showed significantly reduced alpha diversity compared with controls (Shannon P = 0.002; Simpson P = 0.049), and beta diversity significantly differed (weighted Unifrac P = 0.004). The relative abundance of 30 taxa significantly varied including Cyanobacteria, which was enriched in cases compared with

SUBMITTER: Hernandez BY 

PROVIDER: S-EPMC8755591 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature