Molecular and Pathology Features of Colorectal Tumors and Patient Outcomes Are Associated with Fusobacterium nucleatum and Its Subspecies animalis.

ABSTRACT:

Background

Fusobacterium nucleatum (F. nucleatum) activates oncogenic signaling pathways and induces inflammation to promote colorectal carcinogenesis.

Methods

We characterized F. nucleatum and its subspecies in colorectal tumors and examined associations with tumor characteristics and colorectal cancer-specific survival. We conducted deep sequencing of nusA, nusG, and bacterial 16s rRNA genes in tumors from 1,994 patients with colorectal cancer and assessed associations between F. nucleatum presence and clinical characteristics, colorectal cancer-specific mortality, and somatic mutations.

Results

F. nucleatum, which was present in 10.3% of tumors, was detected in a higher proportion of right-sided and advanced-s

SUBMITTER: Borozan I 

PROVIDER: S-EPMC8755593 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature