Mechanisms of Flow-Mediated Dilation of Pial Collaterals and the Effect of Hypertension.

ABSTRACT: Leptomeningeal anastomoses are small distal anastomotic vessels also known as pial collaterals in the brain. These vessels redirect blood flow during an occlusion and are important for stroke treatment and outcome. Pial collaterals have unique hemodynamic forces and experience significantly increased luminal flow and shear stress after the onset of ischemic stroke. However, there is limited knowledge of how pial collaterals respond to flow and shear stress, and whether this response is altered in chronic hypertension. Using an in vitro system, pial collaterals from normotensive and hypertensive rats (n=6-8/group) were isolated and luminal flow was induced with intravascular pressure maintained at 40 mm Hg. Collateral lumen diameter was measured following each flow rate in the absence or pr

SUBMITTER: Li Z 

PROVIDER: S-EPMC8755599 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature