Circulating Sex Hormones and Risk of Colorectal Adenomas and Serrated Lesions in Men.

ABSTRACT:

Background

Sex hormones have been implicated in the etiology of colorectal neoplasia in women for over 40 years, but there has been very little investigation of the role of these hormones in men.

Methods

Using data from an adenoma chemoprevention trial, we conducted a secondary analysis to examine serum hormone levels [testosterone, androstenedione, DHEA sulfate (DHEAS), and sex hormone binding globulin (SHBG)] and risk of colorectal precursors in 925 men. Multivariable logistic regression models were fit to evaluate adjusted associations between hormone levels and risk of "low-risk" (single tubular adenoma < 1 cm) and "high-risk" lesions (advanced adenoma or sessile serrated adenoma or right-sided serrated polyp or >2 adenomas of any size).

Results

Overall, levels of

SUBMITTER: Figueiredo JC 

PROVIDER: S-EPMC8755601 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature