Postdiagnosis BMI Change Is Associated with Non-Small Cell Lung Cancer Survival.

ABSTRACT:

Background

Body mass index (BMI) change after a lung cancer diagnosis has been associated with non-small cell lung cancer (NSCLC) survival. This study aimed to quantify the association based on a large-scale observational study.

Methods

Included in the study were 7,547 patients with NSCLC with prospectively collected BMI data from Massachusetts General Hospital and Brigham and Women's Hospital/Dana-Farber Cancer Institute. Cox proportional hazards regression with time-dependent covariates was used to estimate effect of time-varying postdiagnosis BMI change rate (% per month) on overall survival (OS), stratified by clinical subgroups. Spline analysis was conducted to quantify the nonlinear association. A Mendelian Randomization (MR) analysis with a total of 3,495 patients fur

SUBMITTER: Yuan Q 

PROVIDER: S-EPMC8755617 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature