Ontology highlight
ABSTRACT:
SUBMITTER: Kim E
PROVIDER: S-EPMC8755621 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Kim Eunha E Paik Donggi D Ramirez Ricardo N RN Biggs Delaney G DG Park Youngjun Y Kwon Ho-Keun HK Choi Gloria B GB Huh Jun R JR
Immunity 20211207 1
Children with autism spectrum disorders often display dysregulated immune responses and related gastrointestinal symptoms. However, the underlying mechanisms leading to the development of both phenotypes have not been elucidated. Here, we show that mouse offspring exhibiting autism-like phenotypes due to prenatal exposure to maternal inflammation were more susceptible to developing intestinal inflammation following challenges later in life. In contrast to its prenatal role in neurodevelopmental ...[more]