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In vitro and in vivo MRI imaging and photothermal therapeutic properties of Hematite (α-Fe₂O₃) Nanorods.

ABSTRACT: Herein we report synthesis of hematite (α-Fe₂O₃) nanorods by calcinating hydrothermally synthesized goethite nanorods at 5000C. The structural, optical and MRI imaging guided cancer therapeutic properties of fabricated nanorods have been discussed in this manscript. FESEM and TEM imaging techniques were used to confirm the nanorod like morphology of as prepared materials. As we know that Fe₂O₃ nanorods with size in the range of 25-30 nm exhibit super magnetism. After coating with the PEG, the as prepared nanorods can be used as T₂ MR imaging contrast agents. An excellent T₂ MRI contrast of 38.763 mM^-1s^-1 achieved which is highest reported so far for α-Fe₂O₃. Besides the as prepared nanorods display an excellent photothermal conversion efficiency of 39.5% thus acts as an excellent photothermal therapeutic agent. Thus, we envision the idea of testing our nanorods for photothermal therapy and MR imaging application both in vitro and in vivo, achieving an excellent T₂ MRI contrast and photothermal therapy effect with as prepared PEGylated nanorods.

SUBMITTER: Gulzar A

PROVIDER: S-EPMC8755697 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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In vitro and in vivo MRI imaging and photothermal therapeutic properties of Hematite (α-Fe2O3) Nanorods.

Gulzar Aanisa A Ayoub Nowsheena N Mir Jaffar Farooq JF Alanazi Amer M AM Shah M A MA Gulzar Arif A

Journal of materials science. Materials in medicine 20220112 1

Herein we report synthesis of hematite (α-Fe2O3) nanorods by calcinating hydrothermally synthesized goethite nanorods at 5000C. The structural, optical and MRI imaging guided cancer therapeutic properties of fabricated nanorods have been discussed in this manscript. FESEM and TEM imaging techniques were used to confirm the nanorod like morphology of as prepared materials. As we know that Fe2O3 nanorods with size in the range of 25-30 nm exhibit super m ...[more]

PMID: 35022850

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Project description:Hematite (α-Fe2O3) emerges as an enticing material for visible-light-driven photocatalysis owing to its remarkable stability, low toxicity, and abundance. However, its inherent shortcomings, such as a short hole diffusion length and high recombination rate, hinder its practical application. Recently, oxygen vacancies (Vo) within hematite have been demonstrated to modulate its photocatalytic attributes. The effects of Vo can be broadly categorized into two opposing aspects: (1) acting as electron donors, enhancing carrier conductivity, and improving photocatalytic performance and (2) acting as surface carrier traps, accelerating excited carrier recombination, and deteriorating performance. Critically, the generation rate, distribution, role, and behavior of Vo significantly differ for synthesis methods due to differences in formation mechanisms and oxygen diffusion. This complexity hampers simplified discussions of Vo, necessitating careful investigation and nuanced discussion tailored to the specific method and conditions employed. Among various approaches, hydrothermal synthesis offers a simple and cost-effective route. Here, we demonstrate a hydrothermal synthesis method for Vo introduction to hematite using a carbon source, where variations in the heating rate have not been previously explored in terms of their influence on Vo generation. The analyses revealed that the concentration of Vo was maximized at a heating rate of 16 °C/min, indicative of a high density of surface defects. With regard to photocatalytic performance, elevated heating rates (16 °C/min) fostered the formation of Vo primarily on the hematite surface. The photocatalytic activity was 7.1 times greater than that of the sample prepared at a low heating rate (2 °C/min). These findings highlight the crucial role of surface defects, as opposed to bulk defects, in promoting hematite photocatalysis. Furthermore, the facile control over Vo concentration achievable via manipulating the heating rate underscores the promising potential of this approach for optimizing hematite photocatalysts.

Dataset Information

In vitro and in vivo MRI imaging and photothermal therapeutic properties of Hematite (α-Fe₂O₃) Nanorods.

Publications

In vitro and in vivo MRI imaging and photothermal therapeutic properties of Hematite (α-Fe<sub>2</sub>O<sub>3</sub>) Nanorods.

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