SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB.

ABSTRACT: SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant proportion of infections, individuals develop severe symptoms that can lead to long-lasting lung damage or death. These severe cases are often associated with high levels of pro-inflammatory cytokines and low antiviral responses, which can cause systemic complications. Here, we have evaluated transcriptional and cytokine secretion profiles and detected a distinct upregulation of inflammatory cytokines in infected cell cultures and samples taken from infected patients. Building on these observations, we found a specific activation of NF-κB and a block of IRF3 nuclear translocation in SARS-CoV-2 infected cells. This

SUBMITTER: Neufeldt CJ 

PROVIDER: S-EPMC8755718 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature