Accelerated Epigenetic Age in Normal Cognitive Aging of Korean Community-Dwelling Older Adults.

ABSTRACT:

Background

Epigenetic age acceleration has been studied as a promising biomarker of age-related conditions, including cognitive aging. This pilot study aims to explore potential cognitive aging-related biomarkers by investigating the relationship of epigenetic age acceleration and cognitive function and by examining the epigenetic age acceleration differences between successful cognitive aging (SCA) and normal cognitive aging (NCA) among Korean community-dwelling older adults (CDOAs).

Methods

We used data and blood samples of Korean CDOAs from the Korean Frailty and Aging Cohort Study. The participants were classified into two groups, SCA (above the 50th percentile in all domains of cognitive function) and NCA. The genome-wide DNA methylation profiling array using Illumina I

SUBMITTER: Park J 

PROVIDER: S-EPMC8755943 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature