The Kappa Opioid Receptor and the Sleep of Reason: Cortico-Subcortical Imbalance Following Salvinorin-A.

ABSTRACT:

Background

The mechanisms through which kappa opioid receptor (KOR) agonists induce psychotomimetic effects are largely unknown, although the modulation of this receptor has attracted attention for its clinical use. In this work, we characterize the neuropharmacological effects of salvinorin-A, a highly selective KOR agonist.

Methods

Changes in multimodal electroencephalography, single-photon emission computed tomography, and subjective effects following the acute administration of salvinorin-A are reported. The study included 2 sub-studies that employed a double-blind, crossover, randomized, placebo-controlled design.

Results

The electroencephalography measures showed a marked increase in delta and gamma waves and a decrease in alpha waves while subjects were under t

SUBMITTER: Ona G 

PROVIDER: S-EPMC8756086 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature