Reward Processing in Children With Psychotic-Like Experiences.

ABSTRACT: Alterations to striatal reward pathways have been identified in individuals with psychosis. They are hypothesized to be a key mechanism that generate psychotic symptoms through the production of aberrant attribution of motivational salience and are proposed to result from accumulated childhood adversity and genetic risk, making the striatal system hyper-responsive to stress. However, few studies have examined whether children with psychotic-like experiences (PLEs) also exhibit these alterations, limiting our understanding of how differences in reward processing relate to hallucinations and delusional ideation in childhood. Consequently, we examined whether PLEs and PLE-related distress were associated with reward-related activation in the nucleus accumbens (NAcc). The sample consisted of c

SUBMITTER: Harju-Seppanen J 

PROVIDER: S-EPMC8756103 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature