Increased Radiosensitivity of Solid Tumors Harboring ATM and BRCA1/2 Mutations.

ABSTRACT:

Purpose

Preclinical data indicate that response to radiotherapy (RT) depends on DNA damage repair. In this study, we investigated the role of mutations in genes related to DNA damage repair in treatment outcome after RT.

Materials and methods

Patients with solid tumor who participated in next generation sequencing panel screening using biopsied tumor tissue between October 2013 and February 2019 were reviewed and 97 patients that received RT were included in this study. Best response to RT and the cumulative local recurrence rate (LRR) were compared according to absence or presence of missense, nonsense, and frameshift mutations in ATM and/or BRCA1/2.

Results

Of the 97 patients, five patients harbored mutation only in ATM, 22 in only BRCA1/2, and six in both ATM and B

SUBMITTER: Kim KH 

PROVIDER: S-EPMC8756123 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature