Methylation Pattern Mediated by m⁶A Regulator and Tumor Microenvironment Invasion in Lung Adenocarcinoma.

ABSTRACT:

Background

Recent research has established the existence of epigenetic modulation of the immune response. The possible involvement of RNA-n6-methyladenosine (m⁶A) alteration in tumor microenvironment (TME) cell invasion, on the other hand, is unknown.

Methods

Based on 23 m⁶A regulators, we examined the alteration patterns of m⁶A in 629 LUAD tissues and comprehensively connected these modification patterns with TME cell invasion characteristics. The m⁶A score was calculated, and the m⁶A modification pattern of a single tumor was quantified using principal component analysis. Then, we further verified the expression of m⁶A related enzymes and the role hub gene (NOL10) closely related to survival in lung cancer c

SUBMITTER: Jiang F 

PROVIDER: S-EPMC8756160 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature