LncRNA GAS5 suppresses ovarian cancer progression by targeting the miR-96-5p/PTEN axis.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) play critical roles in the occurrence and progression of various tumors, including ovarian cancer (OC). The lncRNA growth arrest-specific transcript 5 (GAS5) has been shown to be an important modulator in the growth and metastasis of OC cells. Our previous studies confirmed that GAS5 was down-regulated in OC; however, the potential underlying molecular mechanism underlying has not yet been elucidated.

Methods

We screened the Gene Expression Profiling Interactive Analysis (GEPIA) database for the expression of the lncRNA GAS5 in OC. Cell Counting Kit-8 (CCK-8), transwell assay, colony formation assay, flow cytometry analysis, and western blotting were applied to determine the various functions of GAS5 in OC progression. The competing

SUBMITTER: Dong Q 

PROVIDER: S-EPMC8756204 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature