Identification of a novel pyroptosis-related gene signature correlated with the prognosis of diffuse glioma patients.

ABSTRACT:

Background

Diffuse glioma is the most common primary tumor of the central nervous system and has a poor prognosis. Recently, a new type of programmed cell death (PCD), pyroptosis, has been found to be widely involved in the process of tumor diseases. However, the expression of pyroptosis-related genes (PRGs) in diffuse gliomas and their relationship with prognosis have rarely been evaluated.

Methods

In this study, we obtained RNA sequencing and clinical data from the Cancer Genome Atlas (TCGA) database and the Chinese Glioma Genome Atlas (CGGA) of diffuse glioma patients. Simultaneously, differentially expressed PRGs between TCGA-Glioma tumor samples and the normal brain samples from the Genome Tissue Expression (GTEx) were investigated. Besides, univariate and multivariate

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8756210 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature