Herba Rhodiolae alleviates depression via the BDNF/TrkB-GSK-3β signaling pathway.

ABSTRACT:

Background

Depression is one of the most common psychiatric disorders worldwide. Many antidepressant drugs are only effective for specific patients and their long-term use can lead to treatment resistance. There is an ongoing need for more effective antidepressant treatments.

Methods

The rats were exposed to chronic unpredictable mild stress (CUMS) to induce depression model. The glutamate level in the hippocampus was determined by high performance liquid chromatography (HPLC). Protein levels in the tissues were measured using western blotting. The fluid consumption test was performed to evaluate potential anhedonia. Open field test was conducted to evaluate locomotor activity. Forced swimming test was used to evaluate susceptibility to negative mood.

Results

In the p

SUBMITTER: Gao L 

PROVIDER: S-EPMC8756224 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature