Development of a novel necroptosis-associated miRNA risk signature to evaluate the prognosis of colon cancer patients.

ABSTRACT:

Background

Necroptosis is a recently discovered caspase-independent form of cell death which plays an important role in the occurrence and development of cancer. As an important regulatory factor in necroptosis, microRNAs (miRNAs) are important for the development of colon cancer. This study established a novel necroptosis-related miRNA risk signature to evaluate the prognosis of patients with colon adenocarcinoma (COAD).

Methods

The necroptosis-related miRNAs were selected by assessing the differential expression of miRNAs in 459 COAD patient samples and 8 control samples from The Cancer Genome Atlas (TCGA). Selection operator Cox analyses and survival analyses were used to establish the risk signature of 7 miRNAs related to necroptosis. Functional enrichment analysis and n

SUBMITTER: Huang Y 

PROVIDER: S-EPMC8756225 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature