A comprehensive characterization of the transcriptome in enzalutamide resistance prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) contributes to more than 1.2 million newly diagnosed cases and more than 350,000 deaths each year, making it the second most common malignancy and the fifth leading cause of cancer-related deaths in men worldwide. Treatment of PCa is further complicated by drug resistance to enzalutamide. The present study comprehensively details the genomic characteristics of enzalutamide-resistant PCa.

Methods

The determination of enzalutamide-related genes in GSE163240 and GSE136129 was conducted by differential expression analysis, gene set enrichment analysis (GSEA) suggested that these genes were highly correlated with immune-related pathways. Subsequently, network analysis including module analysis and degree analysis and univariable cox analysis were

SUBMITTER: Wang L 

PROVIDER: S-EPMC8756251 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature