Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta-analysis.

ABSTRACT:

Introduction

Corneal confocal microscopy (CCM) is a rapid non-invasive ophthalmic imaging technique that identifies corneal nerve fiber damage. Small studies suggest that CCM could be used to assess patients with diabetic peripheral neuropathy (DPN).

Aim

To undertake a systematic review and meta-analysis assessing the diagnostic utility of CCM for sub-clinical DPN (DPN^- ) and established DPN (DPN⁺ ).

Data sources

Databases (PubMed, Embase, Central, ProQuest) were searched for studies using CCM in patients with diabetes up to April 2020.

Study selection

Studies were included if they reported on at least one CCM parameter in patients with diabetes.

Data extraction

Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD)

SUBMITTER: Gad H 

PROVIDER: S-EPMC8756328 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature