Hemophagocytic lymphohistiocytosis-like toxicity (carHLH) after CD19-specific CAR T-cell therapy.
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ABSTRACT:
SUBMITTER: Hines MR
PROVIDER: S-EPMC8756350 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Hemophagocytic lymphohistiocytosis-like toxicity (carHLH) after CD19-specific CAR T-cell therapy.
Hines Melissa R MR Keenan Camille C Maron Alfaro Gabriela G Cheng Cheng C Zhou Yinmei Y Sharma Akshay A Hurley Caitlin C Nichols Kim E KE Gottschalk Stephen S Triplett Brandon M BM Talleur Aimee C AC
British journal of haematology 20210715 4
Chimeric antigen receptor T-cell (CAR T-cell) therapy is associated with significant toxicities secondary to immune activation, including a rare but increasingly recognised severe toxicity resembling haemophagocytic lymphohistiocytosis (carHLH). We report the development of carHLH in 14·8% of paediatric patients and young adults treated with CD19-specific CAR T-cell therapy with carHLH, occurring most commonly in those with high disease burden. The diagnosis and treatment of carHLH required a hi ...[more]
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