Mucosal gene expression profile of stricturing Crohn's disease: A preliminary study.

ABSTRACT: Intestinal strictures are an important complication of Crohn's disease (CD), with ~40% of patients developing symptomatic obstruction within 10 years of diagnosis. However, there is a paucity of research examining the mechanisms driving the development of fibrotic strictures in CD. The present study aimed to identify the mucosal markers associated with stricturing complications by examining the differences in the gene expression profiles of two patient cohorts: Patients diagnosed with inflammatory CD (n=12) and patients with stricturing CD (n=9). For each patient, a paired sample of inflamed and uninflamed mucosa was isolated and assessed by quantitative PCR using a large panel of genes associated with inflammatory bowel disease. The presents study revealed a significantly increased level

SUBMITTER: Tieranu CG 

PROVIDER: S-EPMC8756406 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature