VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling.

ABSTRACT:

Background

The adherens protein VE-cadherin (vascular endothelial cadherin) has diverse roles in organ-specific lymphatic vessels. However, its physiological role in cardiac lymphatics and its interaction with lymphangiogenic factors has not been fully explored. We sought to determine the spatiotemporal functions of VE-cadherin in cardiac lymphatics and mechanistically elucidate how VE-cadherin loss influences prolymphangiogenic signaling pathways, such as adrenomedullin and VEGF (vascular endothelial growth factor)-C/VEGFR3 (vascular endothelial growth factor receptor 3) signaling.

Methods

Cdh5^flox/flox;Prox1CreER^T2 mice were used to delete VE-cadherin in lymphatic endothelial cells across life stages, including embryonic, p

SUBMITTER: Harris NR 

PROVIDER: S-EPMC8756423 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature