Spatiotemporal Phylodynamics of Hepatitis C Among People Who Inject Drugs in India.

ABSTRACT:

Background and aims

Implementing effective interventions for HCV requires a detailed understanding of local transmission dynamics and geospatial spread. Little is known about HCV phylodynamics, particularly among high-burden populations, such as people who inject drugs (PWID).

Approach and results

We used 483 HCV sequences and detailed individual-level data from PWID across four Indian cities. Bayesian phylogeographic analyses were used to evaluate transmission hotspots and geospatial diffusion of the virus. Phylogenetic cluster analysis was performed to infer epidemiologic links and factors associated with clustering. A total of 492 HIV sequences were used to draw comparisons within the same population and, in the case of coinfections, evaluate molecular evidence for shared

SUBMITTER: Clipman SJ 

PROVIDER: S-EPMC8756458 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature