Metabolic MRI with hyperpolarized [1-¹³C]pyruvate separates benign oligemia from infarcting penumbra in porcine stroke.

ABSTRACT: Acute ischemic stroke patients benefit from reperfusion in a short time-window after debut. Later treatment may be indicated if viable brain tissue is demonstrated and this outweighs the inherent risks of late reperfusion. Magnetic resonance imaging (MRI) with hyperpolarized [1-¹³C]pyruvate is an emerging technology that directly images metabolism. Here, we investigated its potential to detect viable tissue in ischemic stroke. Stroke was induced in pigs by intracerebral injection of endothelin 1. During ischemia, the rate constant of pyruvate-to-lactate conversion, k_PL, was 52% larger in penumbra and 85% larger in the infarct compared to the contralateral hemisphere (P = 0.0001). Within the penumbra, the k_PL was 50% higher in the regions that

SUBMITTER: Bogh N 

PROVIDER: S-EPMC8756460 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature