Chronic co-implantation of ultraflexible neural electrodes and a cranial window.

ABSTRACT: Significance: Electrophysiological recording and optical imaging are two prevalent neurotechnologies with complementary strengths, the combined application of which can significantly improve our capacity in deciphering neural circuits. Flexible electrode arrays can support longitudinal optical imaging in the same brain region, but their mechanical flexibility makes surgical preparation challenging. Here, we provide a step-by-step protocol by which an ultraflexible nanoelectronic thread is co-implanted with a cranial window in a single surgery to enable chronic, dual-modal measurements. Aim: The method uses 1-μm -thick polymer neural electrodes which conform to the site of implantation. The mechanical flexibility of the probe allows bending without breaking and enables long-la

SUBMITTER: Yin R 

PROVIDER: S-EPMC8756486 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature