B cells support the repair of injured tissues by adopting MyD88-dependent regulatory functions and phenotype.

ABSTRACT: Exogenously applied mature naïve B220⁺ /CD19⁺ /IgM⁺ /IgD⁺ B cells are strongly protective in the context of tissue injury. However, the mechanisms by which B cells detect tissue injury and aid repair remain elusive. Here, we show in distinct models of skin and brain injury that MyD88-dependent toll-like receptor (TLR) signaling through TLR2/6 and TLR4 is essential for the protective benefit of B cells in vivo, while B cell-specific deletion of MyD88 abrogated this effect. The B cell response to injury was multi-modal with simultaneous production of both regulatory cytokines, such as IL-10, IL-35, and transforming growth factor beta (TGFβ), and inflammatory cytokines, such as tumor necrosis factor alpha (TNFα), IL-6, and interferon gamma. Cytometr

SUBMITTER: Sirbulescu RF 

PROVIDER: S-EPMC8756564 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature