N-Heterocyclic Carbene Ligand Stability on Gold Nanoparticles in Biological Media.

ABSTRACT: The ability to functionalize gold nanoparticle surfaces with target ligands is integral to developing effective nanosystems for biomedical applications, ranging from point-of-care diagnostic devices to site-specific cancer therapies. By forming strong covalent bonds with gold, thiol functionalities can easily link molecules of interest to nanoparticle surfaces. Unfortunately, thiols are inherently prone to oxidative degradation in many biologically relevant conditions, which limits their broader use as surface ligands in commercial assays. Recently, N-heterocyclic carbene (NHC) ligands emerged as a promising alternative to thiols since initial reports demonstrated their remarkable stability against ligand displacement and stronger metal-ligand bonds. This work explores the long-term

SUBMITTER: Sherman LM 

PROVIDER: S-EPMC8756590 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature