Knowledge graph analytics platform with LINCS and IDG for Parkinson's disease target illumination.

ABSTRACT:

Background

LINCS, "Library of Integrated Network-based Cellular Signatures", and IDG, "Illuminating the Druggable Genome", are both NIH projects and consortia that have generated rich datasets for the study of the molecular basis of human health and disease. LINCS L1000 expression signatures provide unbiased systems/omics experimental evidence. IDG provides compiled and curated knowledge for illumination and prioritization of novel drug target hypotheses. Together, these resources can support a powerful new approach to identifying novel drug targets for complex diseases, such as Parkinson's disease (PD), which continues to inflict severe harm on human health, and resist traditional research approaches.

Results

Integrating LINCS and IDG, we built the Knowledge Graph Analytics

SUBMITTER: Yang JJ 

PROVIDER: S-EPMC8756622 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature