Neuroimmunological investigations of cerebrospinal fluid in patients with recent onset depression - a study protocol.

ABSTRACT:

Background

A proinflammatory response has been suggested to be involved in the pathophysiology of depression in a subgroup of patients. However, comprehensive largescale studies on neuroimmunological investigations of the cerebrospinal fluid (CSF) are lacking and no largescale longitudinal CSF studies comparing patients with depression to healthy controls currently exist.

Methods

A longitudinal case-control study including at least 100 patients with first time depression (ICD-10: F32) within the past year with ongoing symptoms and at least 100 sex and age matched healthy controls with collection of CSF, blood, and fecal samples. All individuals will be evaluated by neurological examination including neurological soft signs, interviewed for psychopathology assessment and have

SUBMITTER: Sorensen NV 

PROVIDER: S-EPMC8756720 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature