Movement disorders associated with neuronal antibodies: a data-driven approach.

ABSTRACT:

Background

Movement disorders can be associated with anti-neuronal antibodies.

Methods

We conducted a systematic review of cases with documented anti-neuronal antibodies in serum and/or cerebrospinal fluid published in PubMed before April 1, 2020. Only patients with at least one movement disorder were included. We used random forests for variable selection and recursive partitioning and regression trees for the creation of a data-driven decision algorithm, integrated with expert's clinical feedback.

Results

Three hundred and seventy-seven studies met eligibility criteria, totaling 844 patients and 13 antibodies: amphiphysin, GAD, GlyR, mGluR1, ANNA-2/Ri, Yo/PCA-1, Caspr2, NMDAR, LGI-1, CRMP5/CV2, ANNA-1/Hu, IgLON5, and DPPX. Stiffness/rigidity/spasm spectrum symptoms

SUBMITTER: Sturchio A 

PROVIDER: S-EPMC8756747 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature