Extensive sequence divergence among bovine respiratory syncytial viruses isolated during recurrent outbreaks in closed herds.

ABSTRACT: The nucleotides coding for the extracellular part of the G glycoprotein and the full SH protein of bovine respiratory syncytial virus (BRSV) were sequenced from viruses isolated from numerous outbreaks of BRSV infection. The isolates included viruses isolated from the same herd (closed dairy farms and veal calf production units) in different years and from all confirmed outbreaks in Denmark within a short period. The results showed that identical viruses were isolated within a herd during outbreaks and that viruses from recurrent infections varied by up to 11% in sequence even in closed herds. It is possible that a quasispecies variant swarm of BRSV persisted in some of the calves in each herd and that a new and different highly fit virus type (master and consensus sequence) became dominan

SUBMITTER: Larsen LE 

PROVIDER: S-EPMC87568 | biostudies-literature | 2000 Nov

REPOSITORIES: biostudies-literature