Multiethnic Prediction of Nicotine Biomarkers and Association With Nicotine Dependence.

ABSTRACT:

Introduction

The nicotine metabolite ratio and nicotine equivalents are measures of metabolism rate and intake. Genome-wide prediction of these nicotine biomarkers in multiethnic samples will enable tobacco-related biomarker, behavioral, and exposure research in studies without measured biomarkers.

Aims and methods

We screened genetic variants genome-wide using marginal scans and applied statistical learning algorithms on top-ranked genetic variants, age, ethnicity and sex, and, in additional modeling, cigarettes per day (CPD), (in additional modeling) to build prediction models for the urinary nicotine metabolite ratio (uNMR) and creatinine-standardized total nicotine equivalents (TNE) in 2239 current cigarette smokers in five ethnic groups. We predicted these nicotine biom

SUBMITTER: Bergen AW 

PROVIDER: S-EPMC8757310 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature