Maternal Obesity and Risk of Early-onset Neonatal Bacterial Sepsis: Nationwide Cohort and Sibling-controlled Studies.

ABSTRACT:

Background

Maternal overweight and obesity are related to risks of pregnancy and delivery complications that, in turn, are associated with newborn infections. We examined the associations between early pregnancy body mass index (BMI; kg/m2) and risk of early-onset neonatal bacterial sepsis (EOS).

Methods

We conducted a nationwide population-based retrospective cohort study of 1 971 346 live singleton infants born in Sweden between 1997 and 2016. Outcome was a culture-confirmed EOS diagnosis. We estimated hazard ratios (HR) of EOS according to BMI using proportional hazard models, and identified potential mediators. Among term infants, we conducted sibling-controlled analyses.

Results

EOS risk per 1000 live births was 1.48; 0.76 in term and 15.52 in preterm infants. Co

SUBMITTER: Villamor E 

PROVIDER: S-EPMC8757322 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature