Low bone mineral density is associated with coronary arterial calcification progression and incident cardiovascular events in patients with chronic kidney disease.

ABSTRACT:

Background

Although it is well known that low bone mineral density (BMD) is associated with an increased risk of cardiovascular disease (CVD) and mortality in the general population, the prognostic role of bone mineral density (BMD) has not been established in the chronic kidney disease (CKD) population. Therefore we aimed to evaluate the association between BMD and the risk of CVD and cardiovascular mortality in patients with predialysis CKD.

Methods

This prospective cohort study was conducted with 1957 patients with predialysis CKD Stages 1-5. BMD was measured using dual-energy X-ray absorptiometry and coronary arterial calcification (CAC) scores were evaluated using coronary computed tomography. The primary outcome was a major adverse cardiovascular event (MACE).

Resul

SUBMITTER: Kim H 

PROVIDER: S-EPMC8757420 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature