Serum anti-CRP antibodies differentiate etiology and predict relapse in acute tubulointerstitial nephritis.

ABSTRACT:

Introduction

Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury with various etiologies. It has been shown that autoimmune-related ATIN (AI-ATIN) has a higher recurrence rate and a greater likelihood of developing into chronic kidney disease compared with drug-induced ATIN, yet misdiagnosis at renal biopsy is not uncommon.

Methods

Patients who were clinicopathologically diagnosed as ATIN from January 2006 to December 2015 in Peking University First Hospital were enrolled. Clinical, pathological and follow-up data were collected. Serum samples on the day of renal biopsy were collected and tested for anti-C-reactive protein (CRP) antibodies. CRP and its linear peptides were used as coating antigens to detect antibodies. Statistical analysis was

SUBMITTER: Huang JW 

PROVIDER: S-EPMC8757425 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature