Temporal signaling, population control, and information processing through chromatin-mediated gene regulation.

ABSTRACT: Chromatin regulation is a key pathway cells use to regulate gene expression in response to temporal stimuli, and is becoming widely used as a platform for synthetic biology applications. Here, we build a mathematical framework for analyzing the response of genetic circuits containing chromatin regulators to temporal signals in mammalian cell populations. Chromatin regulators can silence genes in an all-or-none fashion at the single-cell level, with individual cells stochastically transitioning between active, reversibly silent, and irreversibly silent gene states at constant rates over time. We integrate this mode of regulation with classical gene regulatory motifs, such as autoregulatory and incoherent feedforward loops, to determine the types of responses achievable with duration-depende

SUBMITTER: Mukund A 

PROVIDER: S-EPMC8757591 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature