Oral Microbiome and Gingival Gene Expression of Inflammatory Biomolecules With Aging and Periodontitis.

ABSTRACT: Although data describe the presence and increase of inflammatory mediators in the local environment in periodontitis vs. health in humans, details regarding how these responses evolve in the transition from health to disease, changes during disease progression, and features of a resolved lesion remain unknown. This study used a nonhuman primate model of ligature-induced periodontitis in young, adolescent, adult, and aged animals to document features of inflammatory response affected by age. Rhesus monkeys had ligatures tied and provided gingival tissue biopsy specimens at baseline, 0.5, 1, and 3 months of disease and at 5 months of the study, which was 2 months post-ligature removal for clinically resolved tissues. The transcriptome was assessed using microarrays for chemokine (n =

SUBMITTER: Ebersole JL 

PROVIDER: S-EPMC8757787 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature